Chlorpheniramine: how does it work?

Chlorpheniramine is histamine-1 (H₁) antagonists or antihistamines used to treat upper respiratory tract diseases. Provides temporary relief from symptoms reminiscent of runny nose, sneezing and itchy eyes, nose or throat related to hay fever/allergic rhinitis (Facts & Comparisons, 2023). How it’s working?

How does chorpheniramine work?

Although chlorpheniramine cannot reverse the symptoms of an allergic response, treat the cause, or speed recovery, it may stop the response from progressing. Here’s what’s happening.
AND
The antigen-sensitized mast cell responds to repeated exposure to the antigen by releasing chemical mediators. One of those mediators, histamine, binds to H₁ receptors positioned on effector cells (cells liable for allergic symptoms). This initiates an allergic response that affects the respiratory, cardiovascular, gastrointestinal (GI), endocrine, and intestinal systems.
AND
Chlorpheniramine competes with histamine for H₁-receptor sites on effector cells. By attaching to those sites first, the drug prevents more histamine from binding to effector cells and inhibits systemic allergic reactions. It will stop the progression of symptoms reminiscent of bronchoconstriction and bronchospasm, itching of the nose and throat, runny nose, sneezing, hypotension, rapid heartbeat, vasodilation, hives, swelling and general redness of the skin.

Examples of chlorpheniramine

You could also be conversant in popular brands of chlorpheniramine reminiscent of Aller-Chlor, Allergy, Allergy Relief, Chlor-Trimeton, Chlor-Trimeton Allergy, ChlorHist, Diabetic Tussin Allergy, Ed Chlorped Jr, and Pharbechlor. If these medications are used over-the-counter (OTC) for self-treatment, advise the patient to notify their doctor before use in the event that they have respiratory problems (i.e., chronic bronchitis, emphysema), glaucoma, an enlarged prostate, or are currently taking sedatives or sedatives (Lexicomp, n.d.).

Nursing considerations (Facts and comparisons, 2023)

The usual dose of chlorpheniramine in adults and kids over 12 years of age is 4 mg (immediate release) every 4 to six hours or 12 mg (prolonged release) every 12 hours, with a maximum dose of 24 mg per 24 hours. The US Food and Drug Administration (FDA) doesn’t recommend the usage of chlorpheniramine in infants and kids younger than 2 years of age on account of life-threatening unwanted effects reminiscent of metabolic acidosis, seizures, renal and central nervous system (CNS) failure. depression. The FDA warns against the usage of chlorpheniramine in children over 2 years of age. For children aged 6 to lower than 12 years, the standard dose is 2 mg (immediate-release) every 4 to six hours and the utmost each day dose is 12 mg in 24 hours. There is not any really helpful extended-release dose for kids under 12 years of age.
AND
Delayed-release oral formulations ought to be swallowed whole and never crushed or chewed. Patients ought to be advised that chlorpheniramine may cause CNS depression and that caution ought to be exercised when performing tasks requiring mental alertness, reminiscent of operating machinery or driving. Note: These antihistamines may cause agitation in children and adolescents.
AND
Full details will be present in the leaflet that comes with the medication or within the Nursing2022 Medicines Manual + medicines updates.

AND
Facts and Comparisons (2023, March 3). Chlorpheniramine orally. https://fco.factsandcomparisons.com/lco/action/doc/retrieve/docid/fc_dfc/5549065?cesid=0IQwU9D6dfT

AND
Lexicomp (n.d.). Chlorpheniramine: Drug Information. Retrieved April 11, 2023 from https://www.uptodate.com/contents/chlorpheniramine-drug-information?topicRef=7526&source=see_link

AND AND

AND